A web site called The Windows Club has created a tool they called Ultimate Windows Tweaker which in summary is a "TweakUI for Windows 7 & Vista". It basically is a GUI tool for modifying the operating system and internet explorer user interface settings
Originally TweakUI was an unsupported utility created byMicrosoft which was part a set of tools called PowerToys that allow you to modify to Windows XP system user interface settings, but was never updated.
Ultimate Windows Tweaker is a portable application (e.g. doesn't require installation), and supports the 32 and 64-bit versions of the OS.